science Wed, Jun 17, 2026, 10:11 PM UTC · 2d ago
Structure of the pre-initiation complex explains CMGE biogenesis - Nature
Cryo-electron microscopy and biochemical reconstitution experiments in yeast provide insight into the assembly of the CMGE complex, a helicase that establishes bidirectional DNA replication in eukaryotic cells, and elucidate the role of the firing factor Sld2.
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